000			03735nam a22004457a 4500
003			OSt
005			20250930112538.0
008			250930b |||||||| |||| 00| 0 eng d
040			_a University of Cebu-Banilad _c University of Cebu-Banilad
100			_aBaguio, Charlemagne, _eauthor.
245			_aCytotoxic activity of mangosteen (garcinia mangostana) peel extract against HepG2 and HCT-116 cancer cell line / _cCharlemagne Baguio [ten others].
260			_aCebu City, Philippines : _bUniversity of Cebu-Banilad, _cc2025.
300			_a56 pages : _bcolored illustration ; _c12 cm.
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
504			_aIncludes bibliographical references.
520			_a"Cancer remains a significant global health challenge, ranking as the second leading cause of death worldwide, with substantial morbidity and mortality in the Philippines, particularly from colorectal and liver cancers. While conventional treatments like chemotherapy and radiation reduce mortality, they often lack specificity, fail to prevent metastasis, and are associated with considerable adverse effects. This necessitates the exploration of natural products as safer, more effective therapeutic alternatives. Garcinia mangostana (mangosteen), a Southeast Asian fruit, is traditionally recognized for its health benefits, with its phytochemicals, particularly xanthones, demonstrating antioxidant, antitumor, and cell-modulating properties in various studies. However, the specific in vitro anticancer efficacy and chemoprotective potential of mangosteen peel extract against human colorectal (HCT116) and liver (HepG2) cancer cell lines remain underexplored. This study aimed to evaluate the concentration-dependent cytotoxic activity of mangosteen peel ethanolic extract against HCT116 and HepG2 cells using the MTT assay, and to compare its efficacy with standard chemotherapeutic drugs (5-FU for HCT116, Doxorubicin for HepG2). Results revealed potent cytotoxic effects: the extract achieved 92.89% inhibition against HCT116 cells at 100 µg/mL (comparable to 5-FU's 90.55%), and 92.17% inhibition against HepG2 cells at a lower concentration of 25 µg/mL (exceeding Doxorubicin's 69.94%). Colorimetric examination further confirmed significant metabolic inhibition in treated cells. These findings confirm the extract's cytotoxicity, surpassing the 50% inhibition threshold. The study highlights mangosteen peel extract as a promising natural source for novel anticancer agents, contributing to the knowledge gap regarding under-researched Philippine flora. Further research is warranted to elucidate its mechanisms of action and explore its potential for standardized nutraceutical or pharmaceutical development." --Abstract
521			_aAdult
541			_xApuhin, Mercy Milagros _yCollege of Nursing _zNursing
541			_xApuhin, Mercy Milagros _yCollege of Nursing _zNursing
546			_aText in English
650			_aCancer.
650			_aGlobal health challenge.
650			_aMangosteen _xAsian fruit.
700			_aBudiongan, Christian Brianne, _eauthor.
700			_aDagondon, Elaine, _eauthor.
700			_aEstremos, John Daryll, _eauthor.
700			_aGiberson, Charrise Marie, _eauthor.
700			_aMartinez Kyle, _eauthor.
700			_aNunez, Vea Clarisse, _eauthor.
700			_aPaje, Leo Adrianne, _eauthor.
700			_aRejuso, Jomel Mitzi, _eauthor.
700			_aTapodoc, Jaymel, _eauthor.
700			_aVeraque, Bliss Diana, _eauthor.
942			_2ddc _cTHE
998			_cJanna [new] _d09/30/2025
998			_cJanna [added] _d09/30/2025
999			_c14490 _d14490